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What is AutoGen?
FreshTopic area: Frameworks & Tools · Reference: IBM Think Topics · Indexed: 2026-06-15
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AutoGen's architecture
AutoGen is composed of three main layers.
The core layer
Core is AutoGen’s foundational layer, the basic plumbing and wiring that makes the AutoGen framework function. In Microsoft’s language, “Core API implements message passing, event-driven agents, and local and distributed runtime.” In other words, it allows the agents to talk to each other, empowers them to wake up upon certain event triggers and enables them to run locally on your computer or across various servers.
The AgentChat layer
If Core is plumbing and wiring, AgentChat is something like a prefab home with built-in fixtures. AgentChat presumes (based on prevailing use cases) that most people want AI agents to be able to chat to humans and other bots (in technical terms, to be “conversable agents”). And rather than force developers to code an orchestration logic from scratch, AgentChat further assumes that in multi-agent collaboration, there will be a division of labor, with agent teams frequently including an “AssistantAgent” (which uses LLMs to do “thinking” for the user) as well as a “UserProxyAgent” (for code execution and tool use). This ability to leverage “template” agent teams helps facilitate rapid prototyping of AI applications.
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Real-world use cases of AutoGen
Microsoft has claimed to see hundreds of applications of AutoGen in industries ranging from biotech to consumer packaged goods to telecommunications.2
Education
A professor of physical therapy at Tufts University, Benjamin Stern, has used AutoGen for complex tasks, including the creation of tailored assessments, individualized study guides and tutoring for students transitioning to graduate-level courses. Additionally, he has used agent interactions to simulate patient interviews and has leveraged AutoGen’s “group chat”-like capabilities to foster round-robin debate formats. He also reports using OpenAI Assistant agents through AutoGen.
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Drug discovery
The pharmaceutical firm Novo Nordisk has reported several ways it uses Microsoft’s AI stack to conduct and share reasoning in drug discovery.3 Sam Khalil, the company’s VP of data nsights, reports that AutoGen is “helping us develop a production-ready multi-agents framework.”
Data science
IBM engineers Kelly Abuelsaad and Anna Gutowska have created a Multi-agent RAG with AutoGen application that works from human inputs to gather information from a local corpus of documents. They describe a system where six highly specialized agents (including a planner agent, a research assistant and a report generator, among others) divide and conquer. “No longer do we need to write complex SQL queries to extract relevant data from a knowledge base,” they write. The solution is more scalable than working with one big model, since developers can selectively augment any single agent that becomes a bottleneck.
Occupational safety
On Github, one user has demonstrated how AutoGen could be used to examine images taken from a camera in a potentially dangerous environment like a factory, determining in real-time if any humans present are not wearing a helmet. Through an automation, the system would add a red bounding-box on top of the image to alert safety personnel.
AutoGen vs. AG2
The above has described AutoGen, the Microsoft offering. However, as is so often the case with software projects, there has been a fork in the road. A competing framework, AG2, is touted as an “Open-Source AgentOS for AI Agents” by its creators, including the aforementioned Chi Wang. Formerly at Microsoft, Chi Wang later moved on to Google DeepMind; he appears to have decided to evolve an independent version of AutoGen since leaving Microsoft.
“This isn’t a new framework, it’s basically AutoGen 0.2.34 continuing under a new name,” according to one Reddit user who sought to alleviate confusion.4 One of the main differences between Micosoft’s AutoGen and AG2 is that the latter is community-driven, rather than backed by one large firm. Maintainers of AG2 include Wang, as well as researchers from Meta, IBM, and various universities.5
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